![]() Neutrophils internalize microbes through the process of phagocytosis after which the antimicrobial arsenal of the neutrophil granules is delivered to the phagosome to mediate microbial killing. Neutrophils combat microbes using a suite of defense mechanisms. ![]() Neutrophil activation by pathogen products or the local inflammatory milieu prolongs neutrophil life span and arms these cells with antimicrobial effector functions ( Dale et al. Neutrophils are produced in the bone marrow and then patrol blood vessels, from which they can be rapidly recruited to a site of infection. Neutrophils are now recognized as essential effector cells of innate immunity and key regulators of both innate and adaptive immune responses. ![]() Polymorphonuclear leukocytes were then further classified into eosinophils, basophils, and neutrophils. In 1880, Paul Ehrlich described cells with granules and a lobulated nucleus, and called these cells polymorphonuclear leukocytes.
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